Alterations in cholesterol and fatty acid biosynthesis in rat liver homogenates by aryloxy acids

[摘要]

2,4-Dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid inhibited the incorporation of [2-¹⁴C]mevalonate into cholesterol and non-saponifiable lipids. Both compounds inhibited the conversion of [1-¹⁴C]isopentenyl pyrophosphate into cholesterol and the synthesis of cholesterol and fatty acids from [2-¹⁴C]acetate. There was no inhibition of the conversion of [1-¹⁴C]mevalonate into CO₂. At low concentrations (0.5mm) of the compounds there was a stimulation of acetate incorporation into fatty acids.