The Construction of a Monoclonal Diagnostic System for the Field Detection of V. cholerae

[摘要] Cholera is an acute diarrheal disease that is characterized by massive loss of fluids and electrolytes. If it remains untreated, in its most severe form it may result in death. The causative agent is Vibrio cholerae, which was first described by Robert Koch (1884). The disease is contracted by the ingestion of water or food contaminated by the excreta of persons harbouring the bacilli. Since it is exquisitely sensitive to gastric acid, at least 100 million vibrios are required for infection in a reasonably healthy person, but in a malnourished victim or someone with no gastric acidity, 10,000 to 1 million vibrios can produce disease. The human is the only host of V. cholerae (Smith, 1985).

[发布机构] University:University of Glasgow

[关键词] Biochemistry, Bioengineering, Microbiology