Mechanisms for Anaesthetic Mediated Changes in Drug Disposition

[摘要] Anaesthesia may alter acutely the disposition of drugs in the body. This may be produced by changes in hepatic blood flow, by changes in hepatic drug-metabolising enzyme activity or by changes in the distribution of the drug in the body. The known effect of anaesthesia on these determinants is described. The control of and factors affecting hepatic blood flow are discussed, as are the methods of measuring it. Hepatic drug metabolising enzymes are described. Their activity, mathematical models,methods of assessment and factors altering activity are discussed.

[发布机构] University:University of Glasgow

[关键词] Medicine, Pharmacology