Physiological and Pharmacological Models for Control of Anaesthesia

[摘要] This thesis describes the development of physiological and pharmacological models for the control of anaesthesia. These models form the basis of techniques intended to support the automatic control of anaesthesia. Each technique has been implemented and has performed successfully in the operating theatre. In more detail, the thesis describes the development and use of an estimation scheme, based upon a pharmacological model, to estimate a patient's cardiac output and tissue anaesthetic tensions during anaesthesia. The scheme employs a physiologically-based model of inhaled anaesthetic pharmacokinetics. The thesis describes the representation of physiologically-based pharmacokinetic models, the parameterisation of a physiologically-based model of isoflurane pharmacokinetics, a scheme to match such a. model to individuals, and the simulated and actual performance of the estimation scheme. A physiological model forms the basis of a scheme developed to diagnose inappropriate physiological and pharmacological conditions in the patient's state during anaesthesia. This scheme is based upon a model of homeostasis and the stress response. The thesis describes the development of this model, the performance of a prototype implementation, its development to allow the diagnosis of inappropriate conditions and its diagnostic performance both using stored data and in the operating theatre.

[发布机构] University:University of Glasgow

[关键词] Pharmacology