GENETIC ORGANIZATION OF THE REGION AROUND UNC-15 (I), A GENE AFFECTING PARAMYOSIN IN CAENORHABDITIS ELEGANS

[摘要] In the nematode Caenorhabditis elegans mutants in the gene unc-15 ( I ) affect the muscle protein paramyosin (Waterston, Fishpool and Brenner 1977). We have characterized 20 ethyl methanesulfonate-induced mutations in essential genes closely linked to unc-15 . These lethals defined 16 new complementation groups. In the 0.65 map-unit interval around unc-15 defined by dpy-14 and unc-56 , seven newly identified genes have been mapped relative to five existing genes. At present, the average distance between genes in this region is approximately 0.05 map units. Two genes, unc-15 and unc-13 , are only 0.025 map units apart. Partial fine-structure maps of alleles of these two genes have been constructed. This analysis of unc-15 and genes adjacent to it is the first in a series of genetic and biochemical studies directed towards understanding the control of unc-15 expression.

[学科分类] 医学（综合）