Interactions of Anticonvulsant Drugs With Haem Biosynthesis

[摘要] The porphyrias are a group of genetically inherited diseases, each characterized by a deficiency of a particular enzyme in the haem biosynthetic pathway. This thesis was aimed at resolving if three contentious drugs were safe. These were carbamazepine (CBZ), sodium valproate (VPA) and phenytoin (DPH). Of further interest was a detailed investigation of the effects of CBZ following reports that CBZ treatment resulted in a biochemistry typical of acute intermittent porphyria in non-porphyric individuals. The nature and possible mechanisms of these effects (derepression of ALA-S, depression of porphobilinogen deaminase (PBG-D) activity and an altered urinary porphyrin excretion profile) were investigated at length in man, rat, cell culture and in vitro.

[发布机构] University:University of Glasgow

[关键词] Medicine, Pharmacology