G-Proteins in N.I.D.D.M. and Hypertension

[摘要] G-proteins are guanine-nucleotide-binding regulatory proteins which couple receptors to effector mechanisms; G-protein associated 'second messengers' include cAMP and the phospho-inositides, while other G-proteins are coupled to calcium and potassium channels. The expanding G-protein family (all of which share a common trimeric structure) currently includes at least 12 distinct G-proteins some of which can be identified in plasma membranes using specific antibodies (Western immuno-blotting): antibodies are available against several a subunits (Gsa, Gia1, Gia2, Gia3 and Goa)(which possess receptor and effector binding sites) as well as against B subunits. Function has not yet been ascribed to all G-proteins, but Gsa and Gia2 are concerned with the dual regulation (respectively stimulating and inhibiting) of adenylyl cyclase (AC) catalytic unit activity (A).

[发布机构] University:University of Glasgow

[关键词] Medicine