The Use of Cisplatin in the Management of Appendicular Osteosarcoma in the Dog

[摘要] This dissertation presents analysis of various features of cases of canine osteosarcoma (including one case of chondrosarcoma) managed in the Department of Veterinary Surgery, Glasgow University Veterinary School. These features include: -the clinical outcome in cases managed with surgery and cisplatin chemotherapy - experiences with the use of bone allografts for limb reconstruction following en bloc resection - analysis of certain aspects of the pharmacokinetics of the drug administered to selected patients These findings are presented in the light of published work on the treatment of osteosarcoma and the use of cisplatin in the dog and man. The major conclusions are: - subsets of the tumour may exist, with the potential for varying biological behaviour - the management of osteosarcoma with cisplatin chemotherapy has a positive benefit on survival, in selected patients, but death due to metastatic disease is almost inevitable - the design of chemotherapeutic protocols for canine osteosarcoma is not finalised - though the area under the platinum in plasma ultrafiltrate concentration-time curve gave a consistent value in the clinic at Glasgow University Veterinary School it is not suitable, in isolation, for comparing administration protocols - the use of massive allografts in conjunction with cisplatin chemotherapy requires further evaluation - multi-centre prospective trials would be the way to pursue these goals.

[发布机构] University:University of Glasgow

[关键词] Veterinary science