The Expected Number of Heterozygous Sites in a Subdivided Population

[摘要] A simple, exact formula is derived for the expected number of heterozygous sites per individual at equilibrium in a subdivided population. The model of infinitely many neutral sites is posited; the linkage map is arbitrary. The monoecious, diploid population is subdivided into a finite number of panmictic colonies that exchange gametes. The backward migration matrix is arbitrary, but time independent and ergodic ( i.e. , irreducible and aperiodic). With suitable weighting, the expected number of heterozygous sites is 4 N e u , where N e denotes the migration effective population number and u designates the total mutation rate per gene (or DNA sequence). For diploid migration, this formula is a good approximation if N e ⪢ 1.

[学科分类] 医学（综合）