THE EFFECT OF A SELECTED LOCUS ON LINKED NEUTRAL LOCI

[摘要] The effects produced on linked neutral loci as a selected locus evolves towards its equilibrium value are considered. Significant effects on the neutral loci arise if the recombination fraction between the neutral and selected loci is smaller than the order of magnitude of the selective differences at the selected locus. The effect on gene frequencies at the neutral loci, that is, the hitchhiking effect, is determined, as well as the linkage disequilibrium generated by this hitchhiking effect. One of the more important findings is that significant disequilibrium can be generated between two neutral loci by the evolution of a linked selected locus. Consideration is given to the problem of determining how the effect of selection operating in natural populations can be detected, the question of the establishment of inversions in populations, and also to the nonequilibrium properties of populations.

[学科分类] 医学（综合）