ELECTROPHORETIC VARIATION FOR X-CHROMOSOME-LINKED PHOSPHOGLYCERATE KINASE (PGK-1) IN THE MOUSE

[摘要] Electrophoretic variation for X -chromosome-linked phosphoglycerate kinase (PGK-1) has been found as a polymorphism in feral mice in Denmark. Males from feral sampling or from a variety of genetic crosses have only a single-banded phenotype of the variant PGK-1A type or of the PGK-1B type commonly found among inbred mice. By contrast, three phenotypes were observed among females; two homozygous single-banded types and a heterozygous double-banded type. The X -chromosome linkage of the Pgk-1 locus was determined from the mode of inheritance in F1 and backcross generations and confirmed by the linkage of Pgk-1 and the X -linked markers Hq, Ta and Mo. Pgk-1 showed 29/122 recombinations with Hq , 5/185 with Ta and 0/108 recombinants with Mo . Based on these recombination data, a gene order of Hq—Ta—Pgk-1—Mo is suggested.

[学科分类] 医学（综合）