GENETIC ANALYSIS OF CHROMOMERE 3D4 IN DROSOPHILA MELANOGASTER: THE DUNCE AND SPERM-AMOTILE GENES

[摘要] Both male and female Drosophila that are homozygous deficient for chromomere 3D4 are viable but sterile and lack detectable cAMP-specific phosphodiesterase activity. Two genes have been localized to this region: spermamotile ( sam ) and dunce ( dnc ). The sperm-amotile gene is required for male fertility, and the dunce gene is required for normal learning, female fertility, and cAMP-specific phosphodiesterase activity. The sperm-amotile gene maps 0.24 map units to the left of dunce . The expression of the dunce gene seems to be affected by a chromosomal break to the left of sperm-amotile . The fertility of dunce females varies according to changes in the genetic background and the presence or absence of an X -linked suppressor.

[学科分类] 医学（综合）