Scalloped wings Is the Lucilia cuprina Notch Homologue and a Candidate for the Modifier of Fitness and Asymmetry of Diazinon Resistance

[摘要] The Scalloped wings ( Scl ) gene of the Australian sheep blowfly, Lucilia cuprina , is shown to be the homologue of the Drosophila melanogaster Notch gene by comparison at the DNA sequence and genetic levels. A L. cuprina genomic fragment, which shows strong identity with the Notch ( N ) gene at the molecular level, hybridizes to the location of the Scl gene on polytene chromosomes. The two genes are functionally homologous; the dominant and recessive Notch -like phenotypes produced by mutations in the Scl gene allow these alleles to be classed as N -like or Abruptex -like. The Scl gene is under investigation as a candidate for the fitness and asymmetry Modifier ( M ) of diazinon resistance. We show that M affects the penetrance of wing and bristle phenotypes associated with two Scl alleles in a manner consistent with the M being an allele of Scl . In addition, we report a phenotypic interaction between the diazinon-resistance mutation, Rop-1 , and the same alleles of Scl . We propose that the product of Rop-1 , an esterase, may be involved in cell adhesion in developmental processes involving the Scl gene product.

[学科分类] 医学（综合）