IN SUPPORT OF THE TELOMERE CONCEPT

[摘要] The frequency of recovered X-ray-induced (4000R) rearrangements that, in all probability, mimic terminal deletions of the X chromosome was only one of, roughly, 105 X chromosomes screened for tip deficiencies. Although the single exception looks terminally deleted, it is probably capped by a very short or nonpolytene telomeric segment. It is apparent from these data that the probability of "healing" or stabilization of a terminally deleted X in the zygotic nucleus or developing embryo of Drosophila melanogaster is vanishingly small. The telomeric caps in two obviously interstitial deficiencies that were recovered represent, roughly, 1/500 of the length of a mitotic chromosome. These findings give some indication of the extreme difficulty of detecting short telomeric segments capping either deleted polytene chromosomes or deleted metaphase chromosomes of, for example, humans.

[学科分类] 医学（综合）