The Control of Cyclosporin in Transplantation: Pharmacokinetic Aspects

[摘要] Cyclosporin is a relatively new immunosuppressant drug which has been shown to be useful in prevention of graft rejection following organ transplantation. Its major disadvantage is its toxicity, which appears to be related to high concentrations of the drug. Low concentrations are associated with rejection episodes. The aim of cyclosporin dosing is to achieve cyclosporin concentrations which minimise both toxicity and rejection. Individualisation of therapy is necessary since cyclosporin has a narrow 'therapeutic range' and also exhibits wide pharmacokinetic variability. The aims of this work are to quantify the pharmacokinetic variability of cyclosporin in renal and liver transplant patients in an attempt to improve control of therapy.

[发布机构] University:University of Glasgow

[关键词] Medicine, Pharmacology