ANALYSIS OF THE DOSAGE COMPENSATION OF A SPECIFIC TRANSCRIPT IN DROSOPHILA MELANOGASTER

[摘要] The amount of steady-state level RNA complementary to the X -linked salivary gland secretion polypeptide gene Sgs-4 was measured in male and female third-instar larvae carrying one or two doses of a wild-type allele of the gene. RNA levels were found to be compensated in normal one-dose males and two-dose females and to be dosage-dependent within each sex. The presence of mutant alleles of male-less ( mle ) was found to reduce the level of Sgs-4 transcripts in males. These results support the contentions that dosage compensation is mediated by regulating the level of X -linked gene transcripts and that a product of the mle + gene is involved in this process.

[学科分类] 医学（综合）