γ-GLUTAMYL CYCLOTRANSFERASE: A NEW GENETIC POLYMORPHISM IN THE MOUSE (MUS MUSCULUS) LINKED TO LYT—2

[摘要] Electrophoretically variant forms of γ-glutamyl cyclotransferase have been identified in red cells of inbred mouse strains. Each inbred strain exhibited a major band of activity and a minor band that migrated more anodally. The polymorphism affects the migration of both the major and minor bands in a similar way. F1 hybrids between strains with fast forms (A/J) and strains with the slow forms (C57BL/6J) exhibited a four-banded pattern consistent with co-dominant inheritance. The patterns observed in backcross and F2 mice were consistent with the segregation of a pair of autosomal co-dominant alleles. Recombinant inbred strains and a congenic strain were used to show that the locus controlling γ-glutamyl cyclotransferase ( Ggc ) is linked to Lyt-2 , a lymphocyte alloantigen locus on chromosome 6 , with an estimated map distance of 5.0 ± 2.5 centimorgans.

[学科分类] 医学（综合）