DELETION ANALYSIS OF THE TUMOROUS-HEAD (tuh—3) GENE IN DROSOPHILA MELANOGASTER

[摘要] In the presence of the naturally occurring maternal-effect alleles tuh-1h or tuh-1g , the tuh-3 mutant gene can cause the tumorous-head trait or the sac-testis trait. The tuh-3 gene functions as a semidominant in the presence of the tuh-1h maternal effect. Eye-antennal structures are replaced by posterior abdominal tergites and genital structures. If tuh-1h is replaced by its naturally occurring allele tuh-1g, tuh-3 functions as a recessive hypomorph and the defect switches from anterior to posterior structures, with a male genital-disc defect appearing with variable penetrance. Function and regulation of tuh-3 + may better be understood in light of the cytological localization of tuh-3 either adjacent to or as part of the bithorax complex. The tuh-3 + gene product appears to be essential for normal development, at least in the posterior end of the embryo.

[学科分类] 医学（综合）