A NOTE ON THE BALANCE BETWEEN RANDOM SAMPLING AND POPULATION SIZE (ON THE 30TH ANNIVERSARY OF G. MALÉCOT'S PAPER)

[摘要] Wright's model for the effects of random fluctuations in gene frequency in a population of fixed size is generalized to randomly fluctuating population size, and treated from the viewpoint of G. Malécot, using a martingale convergence theorem. The gene frequency approaches a limit, whose value depends on the actual realization, or history, of the process; that is, convergence is with probability one (or: almost surely) in statistical language. The limit does not necessarily represent a state of fixation of either allele; in particular, the limiting probability distribution is not necessarily trivial. For the special case of deterministically varying population size, a necessary and sufficient condition for such non-triviality is given.

[学科分类] 医学（综合）