Targeted delivery of biological agents

[摘要] Biological agents, including peptides and gene delivery systems (recombinant adenoviral vectors), suffer from a relative lack of native targeting capacity.Improvement of their targeting capacity could significantly increase the efficiency of these agents to provide therapeutic effects.Selective targeting of an anti-oxidant peptide to the vasculature in the SHRSP and administration of a variety of adenovirus (Ad) 35-based vectors into transgenic mice has lead to a significant enhancement in both the effectiveness of the anti-oxidant treatment and increased understanding of the requirements needed for the generation of a successfully targeted Ad35 vector.This helps understanding of the requirements for a successful treatment for cardiovascular disease and cancer.

[发布机构] University:University of Glasgow;Department:Institute of Cardiovascular and Medical Sciences

[关键词] Adenovirus, Anti-oxidant, Targeting