Characterisation of Endogenous Retroviral Elements in Canine DNA

[摘要] Dogs suffer from a variety of neoplastic, immunological, degenerative and proliferative disorders for which a retroviral aetiology is suspected. Despite decades of effort, the significance of retroviruses in canine disease remains obscure. This murky subject has been clouded further by a dearth of information concerning canine endogenous retroviral complement and expression. Previous reports have described retroviral expression in both normal and neoplastic canine tissues; but have not defined the origin of the expression. It was considered of interest to determine whether such expression reflected the presence of endogenous retroviral elements in canine genomic DNA. If such elements were found, their aetiological significance in canine diseases would be investigated.

[发布机构] University:University of Glasgow

[关键词] Veterinary science, Animal diseases, Virology