Oxidative Phosphorylation Controlled by Potassium in Rat Liver Mitochondria

[摘要] References(11)Cited-By(5)The investigation was performed to examine the correlation between int amitochondrial potassium content and oxidative phosphorylation. The results indcated a parallel relationship among them. Endogenous potassium content was controlled by treating mitochondria with relatively small amounts of lead and magnesium. The lead-induced potassium release was accompanied by mitochondrial swelling and H+flux changes. Potassium depletion was also found in aged mitochondria together with decreased respiratory control and oxidative phosphorylation, but these parameters recovered after the addition of potassium ions. These results are discussed in relation to the role of potassium ions in mitochondrial functions.

[学科分类] 分子生物学，细胞生物学和基因