Studies of small intestinal mucosal function and the influence of disease in man

[摘要] The idea behind this thesis developed during my employment at the Department of Gastroenterology, Glasgow Royal Infirmary University NHS Trust, as a Clinical Research Fellow. The department is one of the very few that has been established over the years as a centre for gastrointestinal research and investigations. The studies I performed aimed to take advantage of the availability of techniques for the measurement of protein synthesis using stable (i.e non-radioactive) labelling methods and mass spectrometric analysis to provide comparison of the rates of incorporation of labelled amino acids into mucosal protein sampled by gastrointestinal biopsy when presented intravenously and intragastrically. This project concerns itself with the potential role of the tracer amino acid infusion techniques in the investigation of gastrointestinal diseases particularly those associated with mucosal atrophy and hypertrophy. (Abstract shortened by ProQuest.)

[发布机构] University:University of Glasgow

[关键词] R Medicine (General)