MOLECULAR PHARMACOLOGICAL STUDIES ON DRUG-RECEPTOR COMPLEXES SYSTEM IN DRUG ACTION

[摘要] References(10)Cited-By(1)During studies on acetylcholine-its receptor complexes system in drug action, the authors designed the anticholinergic agent of more fitting structure to acetylcholine (ACh) receptor (1), and synthesized the new compound of dicyclohexyl thionothiolphosphorylcholine (NP245) (2). This compound NP245 has more potency 2.43 times than d-tubocurarine (d-TC) as curare-like action, 3/100 times of neostigmine as anticholinesterase action, and 1/1000 times of atropine as antispasmodic action. Particularly, combining selectively with ACh receptor, it has played the part of a useful tool for researching of the ACh receptor (3). This paper reports experiments on the mode of action of NP245 in vitro and in vivo, moreover, on its metabolic fate in rats.

[学科分类] 药理学