ELECTROSHOCK, LIVER SEROTONIN LEVEL AND TRYPTOPHAN PYRROLASE ACTIVITY IN RATS

[摘要] References(8)Cited-By(1)The preceding paper (1) revealed that electroshock induced the elevation of blood serotonin level which caused the changes of carbohydrate metabolism, i.e., hypoglycemia, hyperlactacidemia, decrease of liver glycogen and disappearance of initial peak in glucose tolerance test in rats. Recent investigation by Frieden et al. (2) has indicated the inhibition of tryptophan pyrrolase (TPO) activity by serotonin and indole derivatives in vitro. In the present study we have therefore investigated the changes of both liver serotonin level induced by electroshock or administration of monoamine oxidase inhibitor (MAOI) and TPO activity.

[学科分类] 药理学