Preventive Effects of Hange-shashin-to on Irinotecan HydrochlorideCaused Diarrhea and Its Relevance to the Colonic Prostaglandin E2 and Water Absorption in the Rat

[摘要] References(31)Cited-By(24)The possible preventive effect of Kampo medicine Hange-shashin-to (TJ-14) on chronic diarrheal symptoms induced by the administration of the anticancer agent irinotecan hydrochloride (CPT-11) was investigated in the rat. Repeated oral administrations of TJ-14 at 125 and 500 mg/kg significantly prevented the reduction in body weight and the onset of chronic diarrheal symptoms due to CPT-11 in a dose-dependent manner, even though it failed to show a definite effect on acute diarrheal symptoms. In addition, treatment with TJ-14 accelerated the healing of the intestinal tract injured by repeated dosing of CPT-11 and inhibited significantly the increase of colonic prostaglandin E2 (PGE2) which is closely related to the onset of diarrhea. TJ-14 also improved colonic water absorption impaired by repeated dosing of CPT-11 in rats. These results demonstrate that TJ-14 is an effective medicine for the prevention and/or treatment of CPT-11-induced chronic diarrheal symptoms.

[学科分类] 药理学

[关键词] CPT-11 (irinotecan hydrochloride);Side effect;Chronic diarrheal symptom;Hange-shashin-to;Large intestine