Suppression of Ischemic Edema in Mice by Manganese-Hyaluronate Conjugate

[摘要] References(15)Cited-By(4)Manganese-hyaluronate conjugate (Mn-HA) was synthesized from a diethylenetriaminepentaacetic acid derivative of hyaluronic acid and manganese ion. The conjugate markedly scavenged superoxide anion in vitro and exhibited much higher anti-inflammatory activity than superoxide dismutase in suppressing paw edema in mice when intravenously injected 30 min before the initiation of ischemia.

[学科分类] 药理学

[关键词] Manganese-hyaluronate conjugate;Ischemic edema;Reactive oxygen species