Quenching of Nitric Oxide by an Oral Carbonaceous Adsorbent

[摘要] References(15)Cited-By(2)The ability of carbonaceous particles (AST-120), originally developed as an enteral adsorbent of uremic toxins, to quench nitric oxide (NO)was tested. NO in solutions prepared by two methods [NO gas bubbling and NO generating system, i.e., decomposition of 1-hydroxy-2-oxo-3-(aminopropyl)-3-isopropyl1-triazene] were determined by a NO-specific reduction of carboxy-2-phenyl-4, 4, 5, 5-tetramethyl-imidazoline-l-oxyl-3-oxide using an electron paramagnetic resonance spectrometry. NO concentrations were less in samples containing increasing concentrations of AST-120. In a separate study, nitrite concentrations in lipopolysaccharide-treated RAW264 cells were significantly less in incubation medium containing AST-120. Thus, AST-120 may be applicable as an enteral anti-NO agent.

[学科分类] 药理学

[关键词] Carbonaceous adsorbent;Nitric oxide;Inflammatory bowel disease