Activin Selectively Abolishes Hippocampal Long-Term Potentiation Induced by Weak Tetanic Stimulation In Vivo

[摘要] References(15)Cited-By(4)Although modulation of hippocampal synaptic plasticity by neurotrophins or growth factors has recently become an extensively investigated subject, there are no reports arguing for the contribution of the transforming growth factor (TGF)-β superfamily. In the present study, we examined the effect of activin, a member of the TGF-β superfamily, on long-term potentiation (LTP) of the dentate gyrus in anesthetized rats. Activin significantly impaired the formation of LTP induced by tetanic stimulation (60 Hz for 0.27 sec), but not that by strong tetanic stimulation (60 Hz for 0.5 sec). These results suggest that activin selectively blocks the induction of LTP evoked by threshold tetanic stimulation.

[学科分类] 药理学

[关键词] Hippocampus;Long-term potentiation;Activin