Differential Roles of the Adrenal Gland in the Suppression of Morphine Antinociceptive Tolerance Development by α- and β-Adrenergic Blockers

[摘要] References(10)Concomitant treatment with phentolamine, an α-blocker, or with propranolol, a β-blocker, suppressed the development of morphine tolerance in shamoperated (Sham) mice. In adrenalectomized (ADX) mice, daily morphine developed tolerance as well as in the Sham group, and concurrent phentolamine suppressed the development of tolerance, whereas such suppression by propranolol was abolished. Supplemental treatment of ADX mice with dexamethasone did not restore the suppressive effect of propranolol. These results suggest that defferent mechanisms underlie the prevention of tolerance development by α- and β-blockers, and that adrenal cortex does not seem to participate in the suppression by β-blockers.

[学科分类] 药理学