Inhibitory Effects of Copiamycin A, a Macrocyclic Lactone Antibiotic, on Gastric H+, K+-ATPase, Acid Secretion and Ulcer Formation

[摘要] References(8)Cited-By(1)When 17 macrocyclic lactone antibiotics were examined for their abilities to inhibit gastric H+, K+-ATPase, copiamycin A was found to have the strongest and relatively specific activity with IC50s of 15.7 μg/ml and > 100 μg/ml against the hog gastric H+, K+-ATPase and the dog kidney Na+, K+-APTase, respectively. Furthermore, this antibiotic inhibited the histamine-induced gastric acid secretion in the isolated gastric mucosal membrane of guinea pigs and the gastric ulcer formation in pylorus-ligated rats.

[学科分类] 药理学