The External Ca2+-Dependence of Acetylcholine-Induced Contracture in Single Innervated and Denervated Skeletal Muscle Cells in Mice

[摘要] References(12)Cited-By(1)We examined morphological differences and compared the Ca2+-dependence between acetylcholine (ACh)-contractures in normal and denervated skeletal muscle cells. ACh (1 μM -1 mM) contracted the normal cells into a jackknife-shape. The higher the concentration of external Ca2+, the greater the ratio of responding cells/total cells observed and the sharper the angles of the “jackknives”. ACh contracted the denervated cells into a compression-form, and the contraction was dependent on the external Ca2+ These results indicate that ACh-contractures in both normal and denervated cells are external Ca2+-dependent.

[学科分类] 药理学