Cytotoxic Action of Triphenyltin on Mouse Thymocytes: A Flow-Cytometric Study Using Fluorescent Dyes for Membrane Potential and Intracellular Ca2+

[摘要] References(14)Cited-By(11)Effects of triphenyltin on mouse thymocytes were examined using fluorescent dyes to monitor membrane potential and intracellular Ca2+. Triphenyltin at 3 × 10-7 M to 1 × 10-6 M hyperpolarized thymocytes and depolarized them at 3 × 10-6 M or more, associated with increasing intracellular Ca2+. Hyperpolarization was suppressed by quinine, but not by tetraethylammonium and 4-aminopyridine, suggesting the involvement of Ca2+-activated K+ current. Triphentyltin failed to hyper-polarize thymocytes in Ca2+-free solution. Results indicate that triphenyltin promotes Ca2+-influx to thymocytes. Such an action of triphenyltin may be related to the immunotoxicity of organotins.

[学科分类] 药理学