Protective Effect of a High Protein Diet against the Toxicity of Some Organophosphorus Compounds in Albino Rats

[摘要] References(24)The present investigation deals with determining the efficacy of a high protein diet (HPD) in combating toxicity in albino rats of some organophosphorus compounds (OPCs) that follow dissimilar metabolic patterns in a living system. As assessed by an increase or decrease in the levels of some biochemical and nutritional parameters, the high protein diet containing 59% protein seems to have a beneficial effect in alleviating toxicity of low but prolonged doses of OPCs over the standard diet (SD) containing 19% protein. OPCs undergoing direct detoxication in a living system like diisopropyl phosphoro-fluoridate (DFP) appear to be more susceptible to HPD than those undergoing biotoxication like EPN (O-ethyl O-p-nitrophenyl phenyl-phosphonothioate) and malathion (S-(1, 2-dicarbethoxyethyl) O, O-dimethyldithio-phosphate).

[学科分类] 药理学