EFFECTS OF SOME SYMPATHOMIMETIC AMINES ADMINISTERED INTRAVENTRICULARLY ON RABBIT'S EEG

[摘要] References(8)Cited-By(4)In the previous paper (1), the author reported that the intraventricular administration of adrenaline induced both the arousal and the restng pattern of EEG in rabbits, and that the intraventricular pretreatment of alpha-adrenergic blocking agents suppressed the appearance of the resting pattern, while the resting or sleep pattern appeared more markedly following the pretreatment with beta-adrenergic blocking agents. These results suggest that the EEG resting pattern induced by the intraventricular administration of adrenaline may be dependent on its alpha action, and that there may be two contrasting effects on EEG depending on the alpha and the beta action of the catecholamine injected intraventricularly. In the present experiment, the author reevaluated these hypotheses by examining effects of the intraventricular administration of noradrenaline, phenylephrine and isoproterenol on rabbit's EEG. Modifications of the effects of intraventricularly administered adrenaline were also studied following the systemic pretreatment of dibenamine or reserpine.

[学科分类] 药理学