HYPERGLYCEMIC ACTION OF 2-(2, 6-DICHLORPHENYL-AMINO)-2-IMIDAZOLINE HYDROCHLORIDE IN-RELATION TO ITS HYPERTENSIVE EFFECT

[摘要] References(15)Cited-By(5)Hoefke and Kobinger reported that 2-(2, 6-dichlorphenylamino)-2-imidazoline hydrochloride, ST-155 (Fig. 1), had a long-lasting hypotensive action in dogs and rabbits (1). Then Kobinger and Walland (2), and Toda et al. (3) also observed the similar results in animal experiments. The mechanism of its action, however, has not been thoroughly understood. Hoefke and Kobinger suggested that the hypotensive action of ST-155 might be due to the inhibition of the center of sympathetic nervous system as well as to the modification of baro- and chemoreceptor reflex (1). From the fact that continuous intracerebroventricular infusion of minute doses of ST-155 (0.1-1.0 μg/kg) lowered the systemic blood pressure in rabbits, Toda et al. supposed that its hypotensive action could be mediated mainly by the central nervous system. But, they also mentioned that the hypotensive action of ST-155 was not explained solely by its action on the central nervous system, since the pretreatment with hexamethonium or guanethidine could not abolished this action (3). It is remarkable that this drug shows a significant difference by species. In rabbits, small doses of ST-155 lower the blood pressure, but the hypotensive action of this drug is not manifestly observed in cats and rats. On the contrary, the efficient antihypertensive doses in rabbits raise the blood pressure in cats and rats. Moreover, it is reported that this drug has a hyperglycemic action and that the species difference is also observed in this hyperglycemic action as in the hypotensive effect (1, 3). In the present report, the mechanism of the hyperglycemic action of ST-155 has been analyzed in rats, since a hyperglycemic response of rats to ST 155 is much more significant than other animals, and the relationship between the effect of this drug on blood pressure and blood sugar has been discussed.

[学科分类] 药理学