THE MECHANISM OF APNEA CAUSED BY INTRAVENOUSLY INJECTED NICOTINE AND AMINOCORDIN

[摘要] References(10)There have been many studies on the respiratory action of nicotine in the recent twenty years, and it has been known that intravenously injected nicotine causes an arrest of respiration. Gold and Brown (1) described it as “nicotine apnea” and divided into two types: brief, primary and prolonged, secondary. The latter, which was observable only after .the application of a large dose, was explained as the peripheral curare-like action of nicotine, because phrenic discharges in action current lasted for a while after the respiration had ceased [Gold and Brown(1), Gold and Modell(2)]. The mechanism of the former, which can be shown in a small dose of nicotine, has not been so far clearly explained. The present study was undertaken to elucidate this mechanism and to find out the same type of apnea, caused by some other drugs.

[学科分类] 药理学