ASPIRIN INHIBITION OF HYPERCALCEMIC EFFECT OF 1α-HYDROXYVITAMIN D3 IN RATS

[摘要] References(4)Cited-By(2)Interaction of calcium regulating hormone, active form of vitamin D3, and aspirin (ASA) was studied in rats. One alpha-hydroxyvitamin D3 (1α-OH-D3) produced a hypercalcemia in parathyroidectomized, thyroparathyroidectornized and thyroparathyroidectomized nephrectomized rats. The effect of 1α-OH-D3 was inhibited by treatment with 200, 50 and 20 mg/kg p.o. of ASA. ASA did not stimulate the gut absorption of calcium in vitamin D deficient rats. These data suggest that ASA acts by inhibiting 1α-OH-D3 induced bone resorption. This is the first report demonstrating the inhibitory effect of ASA on bone resorption as induced by 1α-OH-D3, although partial inhibition of bone resorption in vitro has been reported.

[学科分类] 药理学