Isoproterenol-Induced Facilitation of Norepinephrine Release Does Not Primarily Involve a Local Angiotensin II Mechanism in Guinea Pig Pulmonary Arteries

[摘要] References(13)Cited-By(2)We have attempted to clarify whether or not captopril and 1Sar-8lle-angiotensin II could protect isoproterenol-induced facilitation of norepinephrine release in guinea pig pulmonary arteries loaded with 3H-norepinephrine. Angiotensin I at 1 nM and 30 nM isoproterenol similarly facilitated evoked release of 3H-norepinephrine at 1 Hz. Captopril at 1 μM and 1Sar-8lle-angiotensin II at 10 nM completely prevented angiotensin I-induced facilitation, whereas these pretreatments produced no effect on isoproterenol-induced facilitation. Isoproterenol-induced facilitation of norepinephrine release does not primarily involve a local angiotensin II mechanism.

[学科分类] 药理学