Inhibition of Ifosfamide-Induced Urotoxicity by Disulfiram in Mice

[摘要] References(13)Cited-By(5)The effect of disulfiram on the urotoxicity induced by ifosfamide was studied in mice. Ifosfamide administered intraperitoneally to mice caused a dose-related increase in bladder weight within 48 hr of treatment. Disulfiram prevented ifosfamide-induced bladder damage when administered orally within 1 hr of ifosfamide treatment. The results indicate that disulfiram is an effective protective agent against bladder damage caused by ifosfamide treatment.

[学科分类] 药理学