SOME PHARMACOLOGICAL STUDIES ON THE RENAL CARBONIC ANHYDRASE ACTIVITY AND ELECTROLYTES EXCRETION IN THE RAT

[摘要] References(8)Cited-By(2)Reabsorption of the sodium ion at the renal tubules is the main mechanism for maintaining appropriate water content of the body, and it is finely controlled by vasopressin and pituitary-adrenal hormones. Also, the kidney contains an appreciable amount of carbonic anhydrase which catalyzes exchange of H+ with Na+ in the tubules, and diamox, the potent inhibitor of this enzyme, is used as diuretic. This makes it interesting to study on possible regulatory function of vasopressin and pituitary-adrenal system on the carbonic anhydrase activity. Here will be reported our results of experiments on effect of desoxycorticosterone and alrenalectomy on the enzyme activity and diuresis.As substances impeding renal excretion of other drugs competitively, there are caronamide and benemid. They are used clinically as potentiators of penicillin and other drugs. SKF No. 525-A is a recently developed potentiator of mainly centrally acting drugs. They have been also studied as for their action on renal carbonic anhydrase and electrolyte excretion.

[学科分类] 药理学