COMPARATIVE STUDY OF THE EFFECTS OF STRYCHNINE AND MEGIMIDE ON THE REFLEX ACTIVITIES OF SPINAL CORD IN RABBIT

[摘要] References(18)Cited-By(1)Concerning the mechanism of action of strychnine on the central nervous system, Dusser de Barenne (1) and others have made various reports. Recently Bradley et al. (2) and Eccles (3) observing strychnine suppresses the direct inhibitory action and depresses the polysynaptic inhibition in the spinal cord through electrophysiological studies have expressed a new opinion that this is related to the mode of central excitatory action of strychnine.Morita et al. (4) caught the muscle discharge originating in Golgi's tendon organ. which has been considered to be inhibitory on motoneuron in the spinal cord. Next, Takeuchi (5), one of our colleagues investigated the effects of ether, barbiturate and myanesin on this discharge and other spinal reflex discharges and Kimura (6) that of chlorpromazine on these muscle discharges. We have been able to observe two or three discharges at the same time when the same methods as described in the previous reports were used. Accordingly, we have considered it significant to investigate the mechanism of strychnine action on the spinal cord in the electromyography of rabbit's hindlimb.It was found by Shaw et al. (7) that megimide (β-β-ethyl-methyl glutarimide) has an antagonism towards barbiturates, and Cass (8) comparing megimide with picrotoxin or pentylenetetrazol to its potency of antagonistic action against barbiturates, concluded that megimide is more effective barbiturate antagonist than these analeptics. It has generally been said that such medullary stimulants have different loci of action from that of strychnine and though strychnine produces predominant responses by the functional changes of neuron in the spinal cord, on the contrary, medullary stimulants have strong action at a higher center than the spinal level. Therefore, the authors studying the comparative effect of strychnine and megimide on spinal reflex activities, have tried to discover the difference in spinal action of these two drugs.

[学科分类] 药理学