Increase in Basal Pulse Rate and Blood Pressure by the Diabetic State in KK-CAy Mice, Alloxan-Mice and Streptozotocin-Mice

[摘要] References(11)Cited-By(5)Basal pulse rate (PR) and systolic blood pressure (BP) in the tail artery of diabetic KK-CAy mice were compared with those of alloxan- or streptozotocin (STZ)-induced diabetic ddY mice. Significantly higher PR and BP were obtained by the above three kinds of diabetic states when compared with the pre-diabetic state (KK-CAy) or the non-diabetic state (ddY mice). The PR and BP alteration in diabetic KK-CAy mice were significantly different from the PR one in alloxanmice and from the BP one in STZ-mice, respectively. Both increases in PR and BP by the diabetic state suggest an anticholinergic state.

[学科分类] 药理学