Effect of Buthionine Sulfoximine, an Inhibitor of Glutathione Biosynthesis, on the Selenium-Induced Lethality in Mice

[摘要] References(17)Cited-By(2)The effect of buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) biosynthesis, on the selenium induced-lethality was examined in mice. A single injection of BSO (500 mg/kg, i.p.) markedly decreased the concentration of GSH in the liver after 5 hr. The acute lethality induced by selenium was greatly increased in BSO-treated mice. In contrast, the selenium induced-lethality decreased by pre- and post-treatments of cysteine (100 mg/kg, i.p.) in mice.

[学科分类] 药理学