Changes in Amine Oxidase in Plasma of Rats Treated with Hepatotoxins

[摘要] References(10)Cited-By(2)When allyl formate (AF) was administered to rats, the marked elevation of B-form MAO activity in plasma was found with β-PEA as a substrate. In contrast, in the case of carbon tetrachloride (CCl4), A-form MAO activity elevated predominantly. The deaminations of 5-HT and β-PEA in these plasma treated with AF or CCl4 were not inhibited completely by a high concentration of MAO inhibitor, deprenyl or clorgyline. These results indicate the there may be two or more distinct amine oxidases released from the liver and other organs in response to CCl4 or AF.

[学科分类] 药理学