Effect of Etizolam (Depas®) on Production of Superoxide Anion by Platelet-Activating Factor and N-Formyl-Methionyl-Leucyl-Phenylalanine-Stimulated Guinea Pig Polymorphonuclear Leukocytes

[摘要] References(14)Cited-By(3)Effect of etizolam on platelet activating factor (PAF) and N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced superoxide anion (O2-) production in guinea pig polymorphonuclear leukocytes (PMNL) was investigated. Etizolam showed the inhibitory effect on PAF-induced O2- production concentration dependently, with an IC50 value of 4.7 μM, but it had no inhibitory effect on FMLP-induced O2- production at 100 μM. These results suggest that etizolam has a selectively strong inhibitory effect on PAF-induced O2- production in guinea pig PMNL.

[学科分类] 药理学