Inhalation of Carbon Dioxide Enhances the Coronary Vasodilating Action of Isosorbide Dinitrate in the Dog

[摘要] References(11)Cited-By(1)Two kinds of inspiratory gases, 100% O2 and 81% O2+19% CO2, were used for the artificial respiration. Elevating the inspiratory CO2 tension enhanced the decrease in coronary vascular resistance caused by isosorbide dinitrate (100 μg/kg), without any change in heart rate and systemic arterial pressure. Such a change in coronary vascular resistance was prevented by indomethacin. The results suggested an interaction between isosorbide dinitrate and CO2, which was mediated by prostaglandins.

[学科分类] 药理学