Rolipram as a Discriminative Stimuli: Transfer to Phosphodiesterase Inhibitors

[摘要] References(20)Cited-By(5)Rats were trained to discriminate (±)-rolipram (0.32 mg/kg, i.p.) from saline in a two-lever food-reinforced drug discrimination procedure (FR 10). (±)-Rolipram served as a drug discriminative stimulus, and its discrimination was readily established with a mean of 42 training sessions to achieve criterion performance (at least 80% correct response in the consecutive generalization tests with both saline and (±)-rolipram). Thereafter, this stimulus was stably maintained. The (-)-isomer of rolipram was generalized at about one-third of the training dose of the (±)-compound, but the (+)-isomer was generalized only at 10 times the dose of the (±)-compound. This finding suggests that the (-)-compound is more extensively involved as a stimulus than either (±)-rolipram or the (+)-isomer. Ro20-1724, caffeine and theophylline, which are phosphodiesterase inhibitors, were generalized to (±)-rolipram. This result strongly suggests that phosphodiesterase inhibition may be an important factor involved in (±)-rolipram discrimination.

[学科分类] 药理学