EFFECTS OF DIMORPHOLAMINE ON BLOOD PRESSURE

[摘要] References(14)Cited-By(3)Dimorpholamine in 1 to 4 mg/kg produced an epinephrine-like pressor effect in dogs anesthetized with pentobarbital, the response being reversed by pretreatment with an alpha adrenergic blocker. The pressor effect was often preceded by a transient hypotension with marked slowing of the heart beat which disappeared after bilateral vagotomy or administration of hexamethonium.The major part of the pressor effect disappeared following bilateral adrenalectomy, and was resistant to hexamethonium. The minor part seemed to be composed of direct vascular, cardiotonic and central actions.Dimorpholamine might be referred to as a catecholamine releaser and/or a non-nicotinic ganglion stimulant in a broad sense. This nature was evidenced in the experiments with dogs or cats, but not with rabbits or rats.

[学科分类] 药理学