EFFECTS OF 3, 5, 3'-TRIIODOTHYRONINE ON THE EXPERIMENTAL ATHEROMATOSIS CAUSED BY CHOLESTEROL FEEDING IN RABBITS

[摘要] References(24)Cited-By(1)Though the exact pathogenesis of clinical arteriosclerosis remains still to be settled, experimental atheromatosis in animals such as rats, rabbits, dogs, monkeys and birds caused by cholesterol feeding with or without addition of cholic acids and vegetable or animal oil has widely been available for resolving this problem. Recently, Takaori and Shimamoto (1) and Takaori, Osumi and Shimamoto (2) in this laboratory have shown that the mode of formation of cholesterolemia and cholesterol deposition in the tissues produced by cholesterol feeding markedly differs in rats and rabbits. They have further shown that though hypercholesterolemia and cholesterol deposition in rats spontaneously subside despite the continuation of the cholesterol feeding, spontaneous declination during the feeding term is never observed in rabbits. The lowering effect of thyroactive substances on the elevated level of the serum and tissue cholesterol in the experimental animals has been demonstrated in chickens (3, 4), rats (5) and rabbits (6, 7). Takaori, Osumi and Shimamoto (2) have shown that the administration of 3, 5, 3'-triiodo-4-acetyl-thyroformic acid (TBF-43), a possible metabolite of thyronine, does prompt the spontaneous declination of hypercholesterolemia and cholesterol deposition in the rats, and that the same procedure in the rabbits is almost non-effective, though the subcutaneous fatty tissues are much reduced. In the current report it was attempted to determine whether 3, 5, 3'-triiodothyronine (T3) had similar effects on cholesterolemia and cholesterol deposition compared with TBF-43, and whether the effect, if any, correlated with the lipolytic or thyrotropic mechanism of the compound.

[学科分类] 药理学